Secretory Immunoglobulin A: Introduction
Immunoglobulin is used in patients with primary and secondary immunodeficiency disorders and to combat infections. Immunoglobulin A (IgA, also referred to as sIgA in its secretory form) is an antibody that plays a crucial role in the immune function of mucous membranes.
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sIgA is produced in the largest quantity from the mucous membrane compared to all the other immunoglobulin. Immunoglobulin A represents almost 15% of the total immunoglobulin produced in the body.
IgA is known to exist in monomeric as well as dimeric form and is categorized into two sub-classes, namely IgA1 and IgA2. Secretive immunoglobulin A (sIgA) is the main immunoglobulin found in mucous secretions, including tears, saliva, sweat, colostrum, and secretions from the genitourinary tract, gastrointestinal tract, prostate, and respiratory epithelium. sIgA does not get degraded by the proteolytic enzymes and it protects the mucosal tissues from microbial invasion. The main function of secretory immunoglobulin A is to stop the entry of antigens or foreign substance through the mucosal passage into the circulatory system.
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Key Drivers and Restraints of Global Secretory Immunoglobulin A Market
The global secretory immunoglobulin A market continues to expand at a high growth rate. This growth is driven by increasing prevalence of airway infections, kidney disorders, gonorrhea, and other such serious disorders that significantly reduce sIgA levels in the body. Lower level of sIgA can lead to increased risk factors for patients to develop autoimmune disorders such as rheumatoid arthritis, lupus, allergies, and asthma.
Prevalence of cancer, diabetes, and neurological disorders is rising due to rapidly increasing geriatric population. The geriatric population is more vulnerable to diseases due to poor immunity. This is anticipated to drive demand for better immunological treatments, which in turn would provide opportunities for companies operating in the global secretory immunoglobulin A market.
Moreover, technological improvements in the production and purification methods of immunoglobulin have made these safer and free from protein, viral, or any other contaminant. This has increased clinician preference for usage of immunoglobulin, which in turn is expected to boost demand for secretory immunoglobulin A during the forecast period.
However, high cost of the treatment, chronic side effects, and supply demand gap in the immunoglobulin market is anticipated to restrain the market during the forecast period.
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Biopharmaceutical Industries to Lead the Global Market
The global secretory immunoglobulin A market can be segmented based on end-user, and region
On the basis of end-user, the market can be segmented into biopharmaceutical industries, academic & research institutes, and others. Biopharmaceutical industries is expected to be the major end-user of secretory immunoglobulin A during the forecast period.
North America to Present Lucrative Opportunities in Global Secretory Immunoglobulin A Market
The global secretory immunoglobulin A market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa
North America is projected to continue to dominate the global market. This is due to high adoption of IVIG treatment and high plasma yield. The region is also home to several key players such as CSL Behring LLC and Baxalta, which boosts the market in this region. The region is projected to be the most lucrative market for intravenous immunoglobulin (IVIG) during the forecast period, due to high plasma yield and high per capita health care expenditure.
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Key Players Operating in Market
Leading players operating in the global secretory immunoglobulin A market include:
- Thermo Fisher Scientific
- Biotest AG
- CSL Behring
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