Early Toxicity Testing Market: Introduction

  • An early toxicity testing or screening is the process of safety assessment which determines the level of tissue or cell damage and maximum safe concentration of any chemical or drug. It is generally performed during preclinical development of products.
  • Toxicology testing may also be carried out to determine the approximate amount and type of drugs present in the blood such as alcohol, amphetamine, barbiturates, benzodiazepine, and cocaine.

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  • Key methods used for toxicology testing are in vivo testing, in vitro testing, and in silico testing
  • In vivo testing utilizes test animals to carry out desired testing process. It can be categorized into two types: acute in vivo testing (short-term testing) and chronic in vivo testing (long-term testing).
  • In vitro experimentation uses isolated cells from different organisms, including humans, depending on the type of cell needed to perform the specific research activity
  • In silico method, also known as predictive toxicology testing, is concerned with the development of new non-animal tests that do not simply duplicate existing animal tests but which provide a new scientific basis for safety testing
  • Among the testing methods, the in vivo segment dominates the global toxicology testing services market in terms of value, owing to its high cost

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Key Drivers and Restraints of Global Early Toxicity Testing Market

Rise in Focus on Early Detection of Toxicity of Chemicals Drives Global Market

  • Preclinical toxicology testing studies are carried out for screening the new chemical entity under development in order to analyze its safety and efficacy in animal models before it enters clinical trials in human beings
  • Roughly 30% of drugs tested in clinical trials fail due to unanticipated and unacceptable toxicology profiles
  • Early detection of toxicity during the preclinical phase can prevent large spending on clinical trials, thus saving R&D expenditure and unnecessary exposure of toxic chemicals to healthy human volunteers participating in the clinical trials
  • Thus, the companies involved in the drug development process and the regulatory bodies are focusing on early detection of the toxicity of chemicals
  • For this purpose, toxicology studies are outsourced to an expert team from CROs to speed up the process and reduce costs
  • Thus, rise in focus on early detection of toxicity is expected to propel the global early toxicity testing market during the forecast period

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Early Toxicity Testing Market: Segmentation

  • Based on technique, the global early toxicity testing market can be segmented into in vivo, in silico, and in vitro
  • In vivo toxicology testing procedure leads the global early toxicity testing market, in terms of value, due to high cost associated with this type of testing technique
  • In vivo toxicology testing is lengthy, expensive, and painful to animals used in the testing procedures. Many ethical groups forbid the use of animals for chemical toxicity research and testing. It contributed to new toxicology testing methods, such as in vitro and in silico tests.
  • Based on end-user, the global early toxicity testing market can be categorized into pharmaceuticals industry, cosmetics industry, chemicals industry, food industry, and others

Emerging Economies to Offer Growth Opportunities

  • In terms of region, the global early toxicity testing market can be classified into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa
  • North America constitutes the largest market for early toxicity testing. This can be attributed to stringent regulations by USFDA governing safety assessment of the products, high research & development funds, presence of leading toxicology testing service provider CROs in the region, and high consumer awareness about safety of the products.
  • Asia Pacific is a lucrative market for toxicology testing services. The market in the region is expected to expand at significantly high CAGR during the forecast period. This can be attributed to increase in preference to CROs in this region due to high quality services offered by them in low cost and high speed, presence of skilled labor, and opening of preclinical testing centers in areas such as China, India, Japan, & Australia by leading players in the market.

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Key Service Providers Operating in Global Market

The global early toxicity testing market was highly fragmented in 2018. Key players operating in the global early toxicity testing market include:

  • Laboratory Corporation of America Holdings
  • Charles River Laboratories, Inc.
  • Eurofins Scientific
  • Bureau Veritas
  • Envigo
  • Evotec AG
  • Merck KGaA
  • SGS Group
  • Pharmaceutical Product Development, LLC. (PPD)
  • WuXi AppTec

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