Diazepam (active substance) is indicated for symptomatic relief of anxiety , tension and other somatic or psychological complaints associated with anxiety syndrome . It can also be useful as an adjunct in the treatment of anxiety or agitation associated with psychiatric disorders.

Buy Diazepam, Diazepam (active substance) is useful in relieving reflex muscle spasm due to local trauma (injury, inflammation). It can also be used in the treatment of spasticity due to injury to the spinal and supra-spinal interneurons as occurs in cerebral palsy and paraplegia, as well as in athetosis and rigid syndrome.

Benzodiazepines are indicated only for severe, disabling disorders or for extreme pain.

HOW TO USE DIAZEPAM NEO CHEMISTRY

General

To obtain an optimal effect, the dosage must be individualized. Treatment should be started with the lowest dose appropriate for the particular condition.

Usual oral doses for adults

Starting dose

5 -10 mg. Depending on the severity of the symptoms, 5 – 20 mg / day. Each oral dose for adults should not normally exceed 10 mg.

Duration of treatment

The duration of treatment should be as short as possible. The patient should be regularly reassessed for the need to continue treatment, especially in the asymptomatic patient. Treatment should not exceed two to three months, including the period of progressive withdrawal. Extension beyond this limit may be made after the situation is reassessed. It is useful to inform the patient when treatment is started that it will be of limited duration and explain how the dose will be progressively reduced. In addition, it is important that the patient is alerted about the possibility of the rebound phenomenon, to minimize anxietyabout such symptoms if they occur during withdrawal. There is evidence that, in the case of short-acting benzodiazepines, the withdrawal phenomenon can manifest itself in the interval between doses, especially when the dosage is high. In the case of long-acting benzodiazepines, such as Diazepam (active substance), it is important to prevent when switching to a short-duration benzodiazepine, as withdrawal symptoms may occur.

Instructions for special dosages

Geriatric use

The lowest possible dose should be used in the elderly. These patients should be followed up regularly at the beginning of treatment to minimize dosage and / or frequency of administration, to prevent overdose caused by accumulation.

Liver failure

Patients with liver disorders may have a longer elimination half-life. Patients with severe liver failure should not be treated with Diazepam (active substance). In patients whose liver failure is mild or moderate, the lowest possible dose should be administered.

Diazepam (active substance) must be administered orally.

The tablets can be divided into equal parts to facilitate dosing.

CONTRAINDICATION FOR DIAZEPAM NEO QUÍMICA

Diazepam (active substance) should not be administered to patients with hypersensitivity to benzodiazepines or any excipient in the product, acute angle glaucoma, severe respiratory failure, severe liver failure (as benzodiazepines can lead to the occurrence of hepatic encephalopathy), apnea syndrome sleep or myasthenia gravis . Benzodiazepines are not recommended for primary treatment of psychotic illness. They should not be used as monotherapy in depression or anxiety associated with depression, due to the possibility of suicide in these patients.

PRECAUTIONS

Concomitant use of alcohol / CNS depressants

Concomitant use of Diazepam (active substance) with alcohol and / or CNS depressants should be avoided. Such concomitant use has the potential to increase the clinical effects of Diazepam (active substance), possibly including severe sedation, which can result in clinically relevant coma or death, cardiovascular and / or respiratory depression.

Medical history of alcohol or drug abuse

Diazepam (active substance) should be used with great caution in patients with a history of alcoholism or drug addiction. Diazepam (active substance) should be avoided in patients with dependence on CNS depressants, including alcohol. An exception to alcohol dependence is the management of acute withdrawal reactions.

Liver failure

Benzodiazepines can contribute to the occurrence of episodes of hepatic encephalopathy in patients with severe liver failure. Particular care should be taken when administering Diazepam (active substance) to patients with mild to moderate liver failure.

Psychiatric and “paradoxical” reactions

Psychiatric reactions such as restlessness, agitation, irritability, aggressiveness, anxiety, delusions, anger, nightmares, hallucinations, psychoses, inappropriate behavior and other adverse behavioral effects can occur with the use of benzodiazepines. When this happens, the medication should be discontinued. These effects are more likely in children and the elderly.

Amnesia

It should be borne in mind that benzodiazepines can induce anterograde amnesia, which can occur with the use of therapeutic doses, with an increased risk in larger doses. Amnesic effects can be associated with inappropriate behavior.

Tolerance

Some reduction in response to the effects of benzodiazepines may occur after prolonged use of Diazepam (active substance).

Galactose intolerance

Patients with rare hereditary problems of galactose intolerance (Lapp lactase deficiency or glucose-galactose malabsorption) should not take this medication and should speak to the doctor, as Diazepam (active substance) has lactose in its composition.

Abuse and addiction

Dependency

The use of benzodiazepines and the like can lead to the development of physical or psychological dependence. The risk of addiction increases with the dose and duration of treatment. It is also greater in patients with a medical history of drug or alcohol abuse. Abuses have been reported in users of multiple drugs. Diazepam (active substance) should be used with extreme caution in patients with a history of abuse of alcohol or other drugs. In order to minimize the risk of dependence, benzodiazepines should only be prescribed after careful evaluation as to the indication and should be administered for the shortest possible period of time. The continuation of treatment, when necessary, must be monitored very closely. The prolonged duration of treatment is justified only after careful assessment of the risks and benefits.

Abstinence

When physical addiction occurs, abrupt withdrawal from treatment will be accompanied by withdrawal symptoms. The onset of withdrawal symptoms is variable, lasting from a few hours to a week or more. Headache, diarrhea, muscle pain, extreme anxiety, tension, restlessness, confusion and irritability can occur. In severe cases, symptoms such as depersonalization, derealization, hyperacusis, numbness and tenderness in the extremities, hypersensitivity to light, noise and physical contact, hallucinations or convulsions may occur. In the event of withdrawal symptoms, close medical monitoring and support for the patient are required. Abrupt interruption should be avoided, and a gradual withdrawal scheme should be adopted.

When benzodiazepines are administered, withdrawal symptoms can occur when switching to a benzodiazepine with a considerably shorter elimination half-life.

Rebound anxiety

A transient syndrome with symptoms that led to treatment with Diazepam (active substance) recurs with greater intensity. This can happen with discontinuation of treatment. It may be accompanied by other reactions, including mood swings, anxiety, sleep disturbance and restlessness. As the risk of withdrawal and rebound is greater when the discontinuation of treatment is abrupt, it is recommended that the dosage be reduced gradually.

Special populations

Pediatric use

Benzodiazepines should not be administered to children without careful confirmation of the indication. The duration of treatment should be as short as possible. Since safety and efficacy in pediatric patients under the age of 6 months have not been established, Diazepam (active substance) should be used in this age group with extreme caution and only when other therapeutic alternatives are not available.

Geriatric use

Smaller doses should be used in elderly and debilitated patients.

Respiratory failure

Smaller doses are recommended for patients with chronic respiratory failure because of the risk of respiratory depression.

When cardiorespiratory failure exists, it should be borne in mind that sedatives such as Diazepam (active substance) can accentuate respiratory depression. However, the sedative effect can, on the contrary, have a beneficial effect in reducing the respiratory effort of certain patients. In chronic severe hypercapnia, Diazepam (active substance) should only be administered if the potential benefits outweigh the risks.

Men and women with reproductive potential

If the product is prescribed for a woman of childbearing age, she should contact her doctor to stop the product if she wants to become pregnant or suspects pregnancy.

Pregnancy and lactation

The safety of using Diazepam (active substance) during pregnancy has not been established in humans. Diazepam (active substance) and its metabolites cross the placental barrier. An increased risk of congenital malformation associated with benzodiazepines during the first trimester of pregnancy has been suggested. A review of spontaneously reported adverse effects did not show a higher than expected incidence in a similar untreated population. Benzodiazepines should be avoided during pregnancy unless there is no safer alternative. Before taking Diazepam (active substance) during pregnancy, especially during the first trimester, the possible risks to the fetus (as with any other drug) must be weighed against the expected therapeutic benefit for the mother.

Continuous administration of benzodiazepines during pregnancy can lead to hypotension, reduced respiratory function and hypothermia in the newborn. Withdrawal symptoms in the newborn have occasionally been described with this therapeutic class.

Special care is recommended when Diazepam (active substance) is administered during labor, as a single high dose can produce irregularities in fetal heart rate and hypotonia, difficulty in sucking, hypothermia and moderate respiratory depression in the neonate. remember that the enzyme system involved in the metabolism of the drug is not fully developed in the newborn (especially in premature infants).

As Diazepam (active substance) passes into breast milk, it should not be administered to patients who are breastfeeding.

Effects on the ability to drive a vehicle and operate machinery

Sedation, amnesia, reduced concentration and muscle strength can impair the ability to drive a vehicle or operate machinery. Before receiving Diazepam (active substance), the patient must be advised not to drive a vehicle or operate machinery until he is fully recovered. The doctor must decide when these activities can be resumed.

If sleep duration is insufficient or alcohol is consumed, the likelihood of alertness is compromised is greater.

Patients using Diazepam (active substance) should be alerted to dangerous activities that require great attention, such as operating dangerous machines or driving vehicles. They should also be warned about the concomitant consumption of alcoholic beverages, as there may be an increase in the undesirable effects of both drugs.

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