Nerve growth factor (NGF) is a protein responsible for the development and maintenance of sensory and sympathetic neurons, especially the neurons that transmit touch, temperature, and pain sensation. Studies have shown that nerve growth factor causes axonal growth via axonal branching and elongation.
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The nerve growth factor gene responsible for the secretion of NGF is referred to by names such as beta-nerve growth factor, HSAN5, beta-NGF, nerve growth factor, beta subunit, beta-nerve growth factor precursor, NGFB, and NGF_HUMAN. The NGF protein acts by attaching to the receptors, which kick off the signaling pathway within the cell. The binding of NGF on receptors signals the neuron to develop, mature, and take on the specialized function. It also blocks the signals that initiate apoptosis. Nerve growth factor was first discovered by Levi-Montalcini, Hamburger, and Cohen in 1953 in two mouse sarcomas.
NGF is important for the survival of sensory and sympathetic neurons. It plays a major role in the reduction of neural degeneration. It can be of significant use in inflammatory diseases, where it suppresses inflammation, and in the treatment of multiple sclerosis and psychiatric disorders such as depression, dementia, schizophrenia, rett syndrome, autism, anorexia nervosa, and bulimia nervosa. NGF also plays a role in coronary atherosclerosis, type 2 diabetes, obesity, wound healing, and metabolic syndrome.
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In few gynecological diseases, an increased level of prostaglandin E2 is thought to stimulate the production of NGF, which is responsible for the perception of pain and increased inflammation in endometriosis. An increased level of cortical and subcortical NGF is found in patients with Alzheimer’s disease.
The nerve growth factor market can be segmented based on application and region. Based on application, the nerve growth factor market can be segmented into central neurodegenerative diseases, peripheral neuropathies, autoimmune diseases, and others. In terms of region, the nerve growth factor market can be categorized into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.
North America and Europe are prominent regions of the nerve growth factor market, due to high incidence and prevalence rate of neurodegenerative diseases in the regions. According to the McGovern Institute for Brain Research at MIT, brain disorders contribute significantly to the global disease burden. It has been estimated that in Europe, brain disorders account for around 35% of the disease burden.
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More than one million adults in the U.S. are diagnosed with chronic brain diseases and disorders. Thus, this large base of brain patients is expected to drive the nerve growth factor market in the region. However, other regions such as South East Asia, Middle East, and Latin America are expected to offer expansion potential for the nerve growth factor market in the future. This is due to a high incidence rate of brain diseases and high adoption rate for advanced therapeutics In these regions.
The nerve growth factor market is being driven by a rise in the incidence rate of brain diseases and increase in the geriatric population. Expected technological breakthroughs are estimated to offer attractive opportunities for detecting targeted blockages, monitoring cellular response, and for determining genetic predisposition. This is likely to drive the nerve growth factor market. However, a rise in stringent regulatory policies, increase in overall health care expenditure, and high costs of clinical trials are some of the factors that are projected to restrain the nerve growth factor market in the near future.
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Major players operating in nerve growth factor market include Merck KGaA, Promega Corporation, Alomone Labs, Bio-Rad Laboratories, Inc., Enzo Life Sciences, Inc., Prospec-Tany Technogene Ltd., CUSABIO TECHNOLOGY LLC, and Biocare Medical, LLC.
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