Global Neurocutaneous Disorders Market: Introduction
Neurocutaneous disorder affects the brain, peripheral nerves, and spine. Neurocutaneous disorders comprise a group of central nervous system disorders with simultaneous lesions in the eye, visceral organs, and skin. Tuberous sclerosis, neurofibromatosis, and Sturge-Weber syndrome are the most common neurocutaneous disorders.
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Neurofibromatosis can be of following types: type I, II, and schwannomatosis. According to the National Institute of Neurological Disorders and Stroke (NINDS), neurocutaneous disorders occur in 1 in 6,000 people in the U.S. Neurofibromatosis type I is the most common type of neurocutaneous disorder that affects the nerves outside the brain and spinal cord, called peripheral nerves. Neurofibromatosis type II arises from the central nervous system and affects hearing and balance in affected individuals.
According to the National Institute of Neurological Disorders and Stroke, neurofibromatosis type 1 affects approximately 1 in 3,000 to 4,000 births in the U.S., whereas neurofibromatosis type II has less frequency and is reported in nearly 1 in 25,000 births in the U.S. The cause of Sturge-Weber syndrome is unknown, and the disorder is considered sporadic. Tuberous sclerosis affects retinal areas of the eye and inside of the brain, spinal cord, lungs, skin, kidney, bones, and other parts. It leads to seizures, disability in learning, and neurological disability.
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Individuals affected with Schwannomatosis experience intense pain due to an increase in the size of Schwannoma, as it presses against the nerve and surrounding tissues. Other symptoms associated could include weakness or numbness in fingers and toes. Individuals affected with Sturge-Weber syndrome develop red mark on the face near the eye and forehead. The mark is formed due to accumulation of several blood vessels under the skin. Sturge-Weber syndrome can lead to neurological effects such as muscle weakness, seizures, and disabilities.
Key Drivers of Global Neurocutaneous Disorders Market
Prevalence of genetic disorders
Genetic disorders and congenital abnormalities occur in about 2% to 5% of all live births, account for up to 30% of pediatric hospital admissions and cause about 50% of childhood deaths in industrialized countries. Genetic factors also play a role in the cause of common multifactorial disorders. The importance of these common disorders is progressively increasing among Arab and other Eastern Mediterranean populations.
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Cardiovascular diseases are currently the leading cause of death in numerous countries of the region. According to National Academy of Sciences, the genetic prevalence of AR-IRDs corresponds approximately to 1 case in 1,380 individuals, with 5.5 million people expected to be affected worldwide.
Prevalence of Neurocutaneous Disorders
According to National Library of Medicine, the distribution of phacomatoses included neurofibromatosis type 1 (NF1) in 92.4%, tuberous sclerosis complex (TSC) 3.9%, neurofibromatosis type 2 (NF2) 2.0%, Klippel-Trenaunay syndrome 0.5%, Von Hippel-Lindau syndrome 0.5%, and other sporadic diseases 0.7%. NF1- neurofibromatosis type 1 is the most common and occurs in 1 in 3,000 births. It is autosomal dominantly inherited, and 60% to 70% of NF1 cases are sporadic and caused by genetic mutation. Occurrence of NF3 through NF8 is extremely rare.
North America to Account for Major Share of Global Neurocutaneous Disorders Market
North America is projected to account for a major share of the global neurocutaneous disorders market during the forecast period. Europe is projected to account for the second-largest market share during the forecast period. Increase in investment, strong collaboration among research institutes and private players, and high awareness are anticipated to boost the market in the region during the forecast period.
The global neurocutaneous disorders market in Asia Pacific is estimated to expand at a rapid pace owing to increasing population, high acceptance of new treatment methodologies, and improvement in healthcare infrastructure in countries such as India. The neurocutaneous disorders market in Latin America and Middle East & Africa is expected to expand under the influence of the market in North America and Europe. Increase in focus of major players in these regions is expected to drive the neurocutaneous disorders market in Latin America and Middle East & Africa during the forecast period. However, low awareness acts as a major restrain of the market in these regions.
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Key Players Operating in Global Neurocutaneous Disorders Market
The global neurocutaneous disorders market is highly consolidated owing to the presence of several key players. Leading players operating in the global neurocutaneous disorders market include:
- Valeant Pharmaceuticals International, Inc.
- Allergan
- Syneron Medical Ltd
- Medtronic Plc
- Cutera, Inc.
- St Jude Medical, Inc.
- Pfizer Inc.
- Novartis AG
- Abbott Laboratories Inc.
- UCB S.A.
- Sanofi SA
- Shire Plc
- Hoffmann-La Roche AG
- Aleva Neurotherapeutics SA
- Johnson & Johnson
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