Lentiviral Vectors: Introduction
- Lentiviral vectors are used as a medium to transfer foreign genetic element into another cell. These vectors are produced from lentivirus, which is defined by its long incubation period and can contaminate dividing and non-dividing cells. Lentiviral are vectors that are descended from the virus, known as human immunodeficiency virus, and used to transport genes in the cells, such as mammalian cells. Such vectors are highly capable vehicles for gene delivery for gene treatments.
- Lentiviral vectors are utilized in the treatment of various type diseases including HIV, Alzheimer’s disease and amyotrophic lateral sclerosis, β-thalassemia, sickle cell disease, Metachromatic Leukodystrophy, X-linked Adrenoleukodystrophy, and Wiskott-Aldrich Syndrome
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Key Drivers of Global Lentiviral Vectors Market
- Increase in research & development expenditure on lentiviral vectors from key market players is a major factor driving the global lentiviral vectors market. Increase in prevalence of diseases such as HIV, Alzheimer’s disease, and amyotrophic lateral sclerosis, β-thalassemia, and sickle cell disease is likely to drive the lentiviral vector market during the forecast period. According to World Health Organization, around 38 million people are living with HIV by globally.
- Major market players are focused on inorganic growth strategies such as collaborations and agreements for design and development of new products. For instance, in October 2024, AVROBIO, Inc. signed a worldwide license agreement and a collaborative research funding agreement with The University of Manchester for an investigational lentiviral gene therapy for mucopolysaccharidosis type II (MPS II), or Hunter syndrome. In June 2019, Servier Laboratories signed a collaboration agreement with Yposkesi, Inc. for the development of more novel and innovative vectors.
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First-generation lentiviral vectors segment to be highly promising
- Based on product type, the global lentiviral vectors market can be segmented into first generation, second generation, and third generation
- The first generation lentiviral vector segment accounted for a prominent share of the global lentiviral vectors market in 2019. The segment is expected to dominate the lentiviral vectors market, as it is used in the treatment of various type of diseases. First-generation lentiviral vectors contained a significant portion of the HIV genome, including the gag and pol genes as well as several additional viral proteins.
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HIV segment to expand significantly
- In terms of disease indication, the global lentiviral vectors market can be divided into HIV, β-thalassemia, X-linked Adrenoleukodystrophy, Metachromatic Leukodystrophy, and Wiskott-Aldrich Syndrome. HIV was a prominent segment, in terms of revenue, in 2019. It is anticipated to expand significantly during the forecast period.
- Increase in number of patients with HIV in developed as well as developing region is likely to drive the segment. According to World Health Organization, around 141,552 people were diagnosed with HIV in Europe in 2018.
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Hospitals segment to expand considerably
- In terms of end-user, the global lentiviral vectors market can be divided into hospitals, clinics and research institute. The hospitals segment accounted for a prominent share of the market, in terms of revenue, in 2019. It is anticipated to expand considerably during the forecast period. Increase in number of patients with HIV, Alzheimer’s disease, amyotrophic lateral sclerosis, β-thalassemia, and sickle cell disease that visit hospitals is likely to boost the segment during the forecast period.
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North America to dominate global lentiviral vectors market
- In terms of region, the global lentiviral vectors market can be categorized into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa
- North America dominated the global lentiviral vectors market in 2019. It is expected to maintain its leading position during the forecast period. Dominance of the region can be attributed to an increase in patients with major chronic diseases such as HIV, cancer, neurological disorders, hematological disorders, and rising number of research and development programs.
- The market in Asia Pacific is projected to expand at a significantly high growth rate during the forecast period, owing to the launch of new products and increase in demand for new treatment options for the treatment of diseases such as HIV, cancer, and Alzheimer’s disease
Key Manufacturers Operating in Global Market
The global lentiviral vectors market was highly fragmented in 2019.
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