Merkel Cell Carcinoma (MCC) Treatment Market: Introduction
- Merkel cell carcinoma, also known as neuroendocrine carcinoma of the skin, is a rare and aggressive type of skin cancer that develops from the top layers of the skin. The disease is caused due to prolonged exposure to the sun, weak immunity, or due to idiopathic reasons.
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- Merkel cell carcinoma (MCC) is a rare disease in which malignant cancer cells form in the skin. Merkel cell carcinoma is the second-most common cause of skin cancer death after melanoma. Weak immune system and exposure to the sun induce the effects of merkel cell carcinoma. MCC usually appears as a single painless lump when exposed to the sun. The disease starts in areas of skin exposed to the sun, especially the head and neck, as well as the arms, legs, and trunk. Merkel cell carcinoma grows rapidly into a metastasize at an early stage, by spreading to nearby lymph nodes or skin in distant parts of the body, lungs, brain, bones, or other organs.
- Several tests and procedures can be carried to examine the skin to detect and diagnose carcinoma cells; however, there are certain factors or effects of prognosis and treatment options that decrease the chance of recovery. New developments in skin biopsy approaches enable to image the diseases or infection at the cellular and molecular level, paving the way for early diagnosis and treatment of diseases.
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Key Drivers, Restraints, and Opportunities of Global Merkel Cell Carcinoma (MCC) Treatment Market
- Increasing cases of MCC is a prominent factor propelling the global Merkel cell carcinoma market. As per the report published in the Current Dermatology Reports journal, the estimated annual prevalence of MCC was approximately 0.6 per 100,000 people. The National Cancer Database, has reported that each year approximately 2500 and 1500, novel MCC cases are reported in Europe and the U.S., respectively.
- Rising research and development activities for the treatment of Merkel cell carcinoma is anticipated to propel the market. In May 2017, researchers of Fred Hutchison University and the University of Washington in Seattle reported the results of a small study combining Avelumab with two other treatments. The combination therapy improves T cells generation and attacks the MCC cells. The National Cancer Institute has also commenced a clinical trial involving the investigational study of the drug ipilimumab Merkel cell carcinoma. Curalso recently is in phase 2 clinical study.
- The Merkel cell carcinoma pipeline is anticipated to propel the market. For instance, in December 2018, Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., undertook a phase 3 open-label, single-arm study to evaluate the efficacy of pembrolizumab as first-line therapy in the participants with advanced Merkel cell carcinoma. In December 2018, Incyte Corporation undertook a phase 2 study of INCMGA00012 in participants with metastatic Merkel cell carcinoma.
- The presence of biosimilars for the Merkel cell carcinoma therapy have been observed to fuel the market. For instance, the European Commission approved the first biosimilars Amgevita, from the Amgen pharmaceutical company. It was approved in the US by the FDA, in September 2016.
- However, the high price of therapeutics, lack of awareness among the people, the onset of side-effects are likely to hamper the market during the forecast period. Side-effects of external radiation therapy include nausea, skin changes, diarrhoea, painful sores in the throat and mouth, fatigue, and dry mouth or thick saliva. The side-effects of the radiation are temporary; however, some rare serious side-effects could become permanent. In a few cases, radiation to the chest could even cause lung damage, which may lead to breathing issues and shortness of breath.
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North America to Capture Major Share of Global Merkel Cell Carcinoma (MCC) Treatment Market
In terms of region, the global merkel cell carcinoma treatment market can be segmented into North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. North America dominated the global market due to an increase in funding for the development of research and healthcare infrastructure in the region. Rising incidence of skin cancer diseases, such as MCC, and early phase diagnosis and treatment of diseases are driving the biotechnology & pharmaceutical sector in North America, which in turn is expected to boost the Merkel cell carcinoma (MCC) treatment market in the region in the next few years. Europe is the second-leading market for Merkel cell carcinoma treatment, as there are favorable government policies regarding the development of healthcare infrastructure, well-developed facilities for cancer patients, and increasing number of gene therapy companies in the region. The Merkel cell carcinoma (MCC) treatment market in Asia Pacific is projected to expand at a rapid pace during the forecast period due to rising environmental pollution, changing lifestyle of people, increasing awareness among patients about MCC treatment, and growing per capita expenditure for health insurance in the region. Moreover, economic growth in India and China is boosting healthcare infrastructure as well as expansion of pharmaceutical companies and biotech labs, which is likely to drive the Merkel cell carcinoma (MCC) treatment market in Asia Pacific in the near future.
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Key Players Operating in Global Merkel Cell Carcinoma (MCC) Treatment Market
The global merkel cell carcinoma (MCC) treatment market is highly fragmented, with the presence of various key players. A large number of manufacturers hold a major share in their respective regions. Major players operating in the global merkel cell carcinoma (MCC) treatment market are:
- Pfizer Inc.
- Ono Pharmaceutical Co. Ltd
- Bristol-Myers Squibb Company
- Merck & Co., Inc.
- Amgen Inc.
- AstraZeneca
- Novartis AG
- Oncovir, Inc.
- Teva Pharmaceuticals Industries Ltd
- OncoSec Medical Incorporated
- Biologics, Inc. (McKesson Corporation)
- Millennium Pharmaceuticals, Inc.
- NantKwest, Inc.
- Merck KGaA
- BeiGene Ltd.
- Apcure SAS
- Immune Design Corp.
- Others
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